Abstract
A novel series of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones has been prepared. These compounds showed good PDE 4 inhibitory activity and weak affinity for rolipram's binding site. They also exhibited a good anti-inflammatory profile without emetic side effects.
MeSH terms
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Animals
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Anti-Asthmatic Agents / chemical synthesis
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Anti-Asthmatic Agents / chemistry
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Anti-Asthmatic Agents / pharmacology
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Emetics / chemical synthesis
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Emetics / chemistry
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Emetics / pharmacology
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Guinea Pigs
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In Vitro Techniques
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Models, Molecular
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Phosphodiesterase Inhibitors / chemical synthesis*
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Phosphodiesterase Inhibitors / chemistry
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Phosphodiesterase Inhibitors / pharmacology
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Quinolones / chemical synthesis*
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Quinolones / chemistry
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Quinolones / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-Asthmatic Agents
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Emetics
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Phosphodiesterase Inhibitors
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Quinolones